Multiple interferon stimulated genes synergize with the zinc finger antiviral protein to mediate anti-alphavirus activity.

The zinc finger antiviral protein (ZAP) is a musta lautanen host factor that mediates inhibition of viruses in the Filoviridae, Retroviridae and Togaviridae families.We previously demonstrated that ZAP blocks replication of Sindbis virus (SINV), the prototype Alphavirus in the Togaviridae family at an early step prior to translation of the incoming

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